If you’re dreaming of a Florida Keys escape, picking the right hotel can make all the difference. Whether you crave a beachfront resort with all the family-friendly perks or a quiet, adults-only hideaway where you can truly unwind, the Keys have something special waiting for you. From charming boutique hotels to luxurious spas and marinas, this guide highlights seven top spots you won’t want to miss—each offering unique experiences that could change how you think about a perfect getaway.
Bakers Cay Resort Key Largo, Curio Collection by Hilton
If you’re dreaming of a peaceful escape surrounded by nature, Bakers Cay Resort Key Largo, part of Hilton’s Curio Collection, is the spot you’ll want to check out. Nestled along Florida Bay, this serene tropical haven offers handcrafted furnishings and stunning views that make you feel right at home. You’ll love the family-friendly activities, from water sports to live music, plus a private beach perfect for sunset chills. Hungry? Immerse yourself in Caribbean cuisine and fresh seafood on-site. Best part? It’s pet-friendly, so your furry pals can share the freedom and fun in this tropical environment with you!
Three Waters Resort and Marina, Islamorada
Just a short drive from Key Largo’s peaceful vibes, you’ll find Three Waters Resort and Marina in Islamorada, opening in 2025 and ready to wow you with 214 waterfront rooms spread across 15 lush acres. This lively atmosphere perfectly suits freedom lovers like you, offering multiple pools to lounge by, fishing piers to cast your line in the Sport Fishing Capital, and plenty of water sports to investigate. With nine unique culinary concepts, you’ll enjoy flavors as exciting as the ocean breeze. Three Waters Resort and Marina is your ultimate spot to relax, discover, and savor every moment.
Isla Bella Beach Resort, Marathon
You’ll love how Isla Bella Beach Resort in Marathon greets you with its stunning Greek-inspired design, making you feel like you’ve stepped into a sun-soaked Mediterranean getaway. The beachfront amenities are just as impressive, with a private beach and a huge zero-entry pool perfect for lounging or splashy fun. Whether you’re craving relaxation or a little family excursion, this place has you covered in style and comfort.
Greek-Inspired Architecture
While many resorts in the Florida Keys offer stunning views and relaxing vibes, Isla Bella Beach Resort in Marathon stands out with its eye-catching Greek-inspired design that feels like a trip to the Mediterranean without leaving Florida. You’ll love wandering the beautifully designed grounds, where white columns and blue accents create a distinctive structural experience. This resort boasts nearly a mile-long private beach, five pools, and waterfront dining, blending luxury amenities with charm. If you want a perfect getaway that combines freedom with elegance, Isla Bella Beach Resort is your go-to spot in the Florida Keys.
Beachfront Amenities
If you’re craving a beachfront escape that feels like your own private paradise, Isla Bella Beach Resort in Marathon has you covered with nearly a mile of soft, sandy beach right at your doorstep. This luxury resort offers beachfront amenities that blend relaxation with eco-friendly charm. Imagine unwinding in a serene atmosphere while enjoying:
- A private beach perfect for morning strolls and sunset views
- Five sparkling pools, including a zero-entry pool for easy access
- Dining options serving fresh seafood that taste like the Florida Keys
You’ll feel free, refreshed, and right at home in this eco-friendly haven.
Little Palm Island Resort & Spa
Since getting to Little Palm Island Resort & Spa means hopping on a boat or seaplane, you know you’re in for a special treat right from the start. This adults-only private island offers a truly secluded experience with 30 luxurious bungalow suites, each boasting thatched roofs and tropical chic vibes. You’ll love the fine dining featuring fresh local seafood, plus private beach access perfect for unwinding. Don’t miss the full-service spa to pamper yourself. Little Palm Island also practices eco-friendly methods, so you can relax knowing your getaway respects nature. It’s freedom and luxury wrapped into one unforgettable escape.
La Concha Key West, Autograph Collection
You’ll love how La Concha Key West, Autograph Collection, blends historic charm with fresh, modern style right on lively Duval Street. After a $35 million makeover, the hotel keeps that island vibe alive while giving you all the comforts you want. Plus, being just steps from the best nightlife and dining means you can easily discover without worrying about a long walk back—how cool is that?
Historic Charm Meets Modernity
While strolling down the lively Duval Street, you’ll find La Concha Key West, a hotel that perfectly blends historic charm with modern style after its impressive $35 million makeover in 2025. This spot offers a unique experience that captures Key West’s colorful culture. Imagine yourself relaxing at the rooftop pool, savoring local flavors at the dining options, and soaking in island-inspired art in your room. You’ll love:
- Stunning views of the Gulf of Mexico
- A lively bar and restaurant serving fresh, local dishes
- A cozy vibe mixing old-world charm with fresh, modern details
Freedom never felt so stylish!
Prime Duval Street Location
Nothing beats staying right on Duval Street when you want to immerse yourself in the heart of Key West’s excitement, and La Concha Key West, Autograph Collection, nails that spot perfectly. This hotel blends historical charm with island-inspired décor, giving you a stay that’s both rich and relaxed. From your room, you’re steps away from lively nightlife and local flavors that make Key West buzz. After exploring, unwind at the rooftop pool with panoramic views—perfect for sunset lovers. Among hotels in Key, La Concha offers the freedom to engage in fun or chill out, making your perfect getaway truly unforgettable.
The Marker Waterfront Resort Key West
Since you want to be right in the heart of Key West’s action, The Marker Waterfront Resort Key West is a fantastic choice that puts you just a short walk from Old Town and the lively Duval Street. At this resort, you’ll enjoy a comfortable stay surrounded by tropical gardens and a modern coastal style that feels fresh and inviting. Immerse yourself in the colorful local culture with:
- Water sports activities right at your fingertips
- A large pool area perfect for unwinding
- Delicious local cuisine featuring fresh seafood
The Marker Waterfront Resort truly blends relaxation with exploration.
Cheeca Lodge & Spa
If you’re craving a perfect mix of luxury and escapade, Cheeca Lodge & Spa in Islamorada is the spot you’ll want to check out. With its private beach and stunning ocean views, you can relax or immerse yourself in thrilling water sports. Exploration seekers will love fishing, golfing, and discovering the tropical ambiance. The resort’s dining options range from laid-back beach bars to fresh seafood restaurants, satisfying every craving. Plus, Cheeca Lodge & Spa leads in sustainability, protecting the beautiful Florida Keys while giving you an unforgettable, eco-friendly getaway. Freedom and fun? Absolutely!
Final Thoughts
You’re just a booking away from an unforgettable Florida Keys getaway! Whether you want family fun at Bakers Cay, luxury vibes at Little Palm Island, or historic charm in Key West, these hotels have you covered. Immerse yourself in water sports, savor tasty meals, or just relax with stunning views—you’ll find the perfect spot to recharge and make incredible memories. So, pack your bags and get ready for a trip that’s as unique and beautiful as the Keys themselves!
